The only branch in the City Centre is moving home.
Post Office has confirmed it will be closing its branch in The Galleries on the 13th of March.
The WHSmith on the middle floor of the shopping centre will be operating Post Office services instead, from the 14th.
There will apparently be eight serving positions and seven self-service machines.
A Post Office spokesperson said: "Following a period of local public consultation and review, we have made the decision to proceed with the proposal to relocate The Galleries Post Office into WHSmith at 27 The Galleries, Broadmead, Bristol where it will be operated by WHSmith High Street Ltd.
"The new branch at WHSmith will open on Thursday 14 March at 9am and will see the Post Office incorporated alongside a retail offer of stationery, gifts and greetings cards. The branch will be open seven days a week.
"The new branch will be operated by WHSmith Ltd, who have successfully operated Post Office branches for a number of years.
"There will be eight serving positions and seven self-service machines. Services will be available from 9am to 5:30pm Monday – Saturday and 11 am to 3pm on Sundays."
Roger Gale, Post Office Network and Sales director, said: “The Post Office is committed to keeping our services at the heart of communities which we know is hugely important to people.
"This change means we can continue to do that, into the future.
"We are making sure we take the right action to sustain services for years to come.”
James Cox, Liberal Democrat Parliamentary Spokesperson for Bristol West, said: "This is a real let down for local people.
"The decision to close and downsize made no sense from the start and it's frustrating that the Post Office has essentially said 'we've listened, but we're ignoring you'.
"This isn't a failing branch, it's the most popular in Bristol and one of the most in the entire South West of England. Downgrading the branch means Bristolians will get a downgraded service.
"Liberal Democrats demand better."
The current Galleries Post Office will close at 17.30 on Wednesday 13 March 2019.